Longevity & Healthy Ageing
Ageing biology, fasting, NAD, senolytics, sauna, cold and the honest evidence. 14 evidence-based guides, each written in plain English with UK context and real citations.
Advanced glycation end-products (AGEs): how sugar and heat age you
AGEs are sugar-damaged proteins linked to ageing, diabetes and heart disease. Learn the real mechanism, the honest evidence, and how to lower your burden.
Read guide → Longevity & Healthy AgeingAutophagy, the cell's recycling system: what fasting actually does
Autophagy is the cell recycling system explained: what it is, how mTOR and AMPK control it, what fasting does, and the honest human evidence vs mouse hype.
Read guide → Longevity & Healthy AgeingCellular senescence and senolytics: zombie cells, hype vs evidence
Senescent zombie cells and the SASP drive ageing. An honest look at senolytics like dasatinib, quercetin and fisetin: strong mouse data, early human trials.
Read guide → Longevity & Healthy AgeingCold water and ice baths: what the evidence actually shows
Cold water and ice baths: the real physiology, the honest evidence on mood, metabolism and immunity, the muscle-gain catch, and the serious safety risks.
Read guide → Longevity & Healthy AgeingIntermittent fasting protocols compared: what the evidence really shows
Compare 16:8, OMAD, 5:2 and alternate-day fasting: what randomised trials show for weight loss and metabolic markers, plus why benefits track calories.
Read guide → Longevity & Healthy AgeingMitochondrial health: how to build more cellular energy
Mitochondria make most of your cellular energy. How exercise, cold, heat and supplements like CoQ10 and urolithin A really affect them, evidence-graded here.
Read guide → Longevity & Healthy AgeingNAD+, NMN and NR: what the longevity evidence actually shows
NAD+ levels fall with age, and NMN and NR aim to restore them. We separate hype from evidence: what the human trials, sirtuins and safety data really show.
Read guide → Longevity & Healthy AgeingOxidative stress and antioxidants: why more is not better
Oxidative stress explained honestly: why high-dose antioxidant supplements failed or harmed in major trials, and why food beats pills for your health.
Read guide → Longevity & Healthy AgeingPolyphenols (resveratrol, quercetin, curcumin): what the evidence really shows
Polyphenols such as resveratrol, quercetin and curcumin: the honest evidence, the bioavailability problem, and why whole foods beat most supplements.
Read guide → Longevity & Healthy AgeingRapamycin and metformin for longevity: what is actually known
Rapamycin and metformin for longevity, the honest evidence: strong mouse data, no human lifespan proof, the TAME trial, real risks, and a sober verdict here.
Read guide → Longevity & Healthy AgeingSauna and heat exposure: the cardiovascular and longevity evidence
Frequent sauna use is linked to lower cardiovascular and all-cause mortality in Finnish men. The evidence, mechanisms, frequency, limits and safety, explained.
Read guide → Longevity & Healthy AgeingSpermidine: the dietary autophagy inducer
Spermidine triggers autophagy and is linked to lower mortality, but the one rigorous memory trial was negative. The foods, doses and the honest evidence here.
Read guide → Longevity & Healthy AgeingThe glymphatic system: how deep sleep helps clear waste from the brain
How deep sleep may flush waste from the brain through the glymphatic system, the amyloid and Alzheimer's link, the honest caveats, and what genuinely helps.
Read guide → Longevity & Healthy AgeingThe hallmarks of ageing: a practical map
The twelve hallmarks of ageing in plain English: what each one is, why they interconnect, and which everyday habits map to which, with an honest verdict here.
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